Nuclear envelope invaginations and cancer.

Journal article

Abstract:: The nuclear envelope (NE) surrounds the nucleus and separates it from the cytoplasm. The NE is not a passive structural component, but rather contributes to various cellular processes such as genome organization, transcription, signaling, and stress responses. Although the NE is mostly a smooth surface, it also forms invaginations that can reach deep into the nucleoplasm and may even traverse the nucleus completely. Cancer cells are generally characterized by irregularities and invaginations of the NE that are of diagnostic and prognostic significance. In the current chapter, we describe the link between nuclear invaginations and irregularities with cancer and explore possible mechanistic roles they might have in tumorigenesis.

Journal:: Advances in experimental medicine and biology More from this journal
Volume:: 773
Pages:: 523-535
Publication date:: 2014-01-01
DOI:: 10.1007/978-1-4899-8032-8_24
ISSN:: 0065-2598

Language:: English
Keywords:: Nuclear Envelope

Neoplasms

Humans

Prognosis

Cell Transformation, Neoplastic
Pubs id:: pubs:450928
UUID:: uuid:dadd8e02-336a-4772-8d3c-e77ce8235852
Local pid:: pubs:450928
Source identifiers:: 450928
Deposit date:: 2014-05-13

Licence:: Terms and Conditions of Use for Oxford University Research Archive

If you are the owner of this record, you can report an update to it here: Report update to this record