Journal article
The RFTS domain of Raf2 is required for Cul4 interaction and heterochromatin integrity in fission yeast
- Abstract:
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Centromeric heterochromatin assembly in fission yeast is critical for faithful chromosome segregation at mitosis. Its assembly requires a concerted pathway of events whereby the RNA interference (RNAi) pathway guides H3K9 methylation to target sequences. H3K9 methylation, a hallmark of heterochromatin structure, is mediated by the single histone methyltransferase Clr4 (equivalent to metazoan Suv3-9), a component of the CLRC complex. Loss of or defects in CLRC components disrupts heterochromat...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.2MB, Terms of use)
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- Publisher copy:
- 10.1371/journal.pone.0104161
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Bibliographic Details
- Publisher:
- Public Library of Science
- Journal:
- PLoS ONE More from this journal
- Volume:
- 9
- Issue:
- 8
- Pages:
- e104161
- Publication date:
- 2014-08-04
- Acceptance date:
- 2014-07-11
- DOI:
- EISSN:
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1932-6203
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:478843
- UUID:
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uuid:d8bc13b7-cd89-4db4-9981-6d201bd33395
- Local pid:
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pubs:478843
- Source identifiers:
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478843
- Deposit date:
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2014-09-12
Terms of use
- Copyright holder:
- White et al
- Copyright date:
- 2014
- Notes:
- © 2014 White et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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