Thesis
Qualitative and quantitative approaches to modelling tyrosine kinase inhibitor treatment and resistance in non-small cell lung cancer
- Abstract:
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Non-small cell lung cancer (NSCLC) affects 80-85% of lung cancer patients. Tyrosine kinase inhibitors (TKIs) are targeted therapies that bind to NSCLC cells with specific mutations and inhibit their growth. However, responses to these therapies generally fail due to the emergence of drug resistance and the onset of adverse events which can include; interstitial lung disease (ILD), edema, hypothyroidism, nausea and diarrhoea. Mathematical models can increase our understanding of the biologi...
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- Files:
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(Preview, Dissemination version, pdf, 11.7MB, Terms of use)
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Authors
Contributors
+ Byrne, H
- Institution:
- University of Oxford
- Division:
- MPLS
- Department:
- Mathematical Institute
- Research group:
- Wolfson Centre for Mathematical Biology
- Oxford college:
- Keble College
- Role:
- Supervisor
- ORCID:
- 0000-0003-1771-5910
+ Gaffney, E
- Institution:
- University of Oxford
- Division:
- MPLS
- Department:
- Mathematical Institute
- Research group:
- Wolfson Centre for Mathematical Biology
- Oxford college:
- Brasenose College
- Role:
- Supervisor
- ORCID:
- 0000-0002-6888-4362
+ Yates, J
- Institution:
- AstraZeneca
- Role:
- Supervisor
+ Baker, R
- Institution:
- University of Oxford
- Division:
- MPLS
- Department:
- Mathematical Institute
- Research group:
- Wolfson Centre for Mathematical Biology
- Oxford college:
- St Hugh's College
- Role:
- Examiner
- ORCID:
- 0000-0002-6304-9333
+ Chappell, M
- Institution:
- University of Warwick
- Role:
- Examiner
+ Engineering and Physical Sciences Research Council
More from this funder
- Funder identifier:
- http://dx.doi.org/10.13039/501100000266
- Funding agency for:
- Carrick Smith, EJ
- Programme:
- EPSRC Centre for Doctoral Training Systems Approaches to Biomedical Sciences
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- Keywords:
- Subjects:
- Deposit date:
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2023-02-18
- ARK identifier:
Terms of use
- Copyright holder:
- Carrick Smith, EJ
- Copyright date:
- 2021
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