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Structural, biochemical and inhibition studies on hypoxia-inducible factor (HIF) prolyl hydroxylases

Abstract:

In humans and other animals, the chronic hypoxic response is mediated by the hypoxia-inducible transcription factors (HIFs), which regulate the expression of genes that counteract the effects of limiting oxygen. HIF prolyl hydroxylases (PHDs) regulate cellular levels and transcriptional activity of HIFs by catalysing the post-translational hydroxylation of conserved prolyl residues in the HIFα subunits. Based on structural and biophysical studies, it has been proposed that the three human ...

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Chemical Biology
Role:
Author

Contributors

Department:
University of Oxford
Role:
Supervisor

DOI:
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

Language:
English
UUID:
uuid:c5c6fad2-fc75-4c40-933a-b5343f4e1006
Deposit date:
2018-09-23
ARK identifier:

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