Journal article

XPF protein levels determine sensitivity of malignant melanoma cells to oxaliplatin chemotherapy: Suitability as a biomarker for patient selection

Abstract:: As the options for systemic treatment of malignant melanoma (MM) increase, the need to develop biomarkers to identify patients who might benefit from cytotoxic chemotherapy becomes more apparent. In preclinical models, oxaliplatin has activity in cisplatin-resistant cells. In this study, we have shown that oxaliplatin forms interstrand crosslinks (ICLs) in cellular DNA and that loss of the heterodimeric structure-specific endonuclease XPF-ERCC1 causes hypersensitivity to oxaliplatin in mammal...
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Publication status:: Published

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APA Style

Hatch, S., Swift, L., Caporali, S., Carter, R., Hill, E., Macgregor, T., D'Atri, S., Middleton, M., McHugh, P., & Sharma, R. (2014). XPF protein levels determine sensitivity of malignant melanoma cells to oxaliplatin chemotherapy: Suitability as a biomarker for patient selection. International Journal of Cancer, 134(6), 1495–1503.

MLA Style

Hatch, S., et al. “XPF Protein Levels Determine Sensitivity of Malignant Melanoma Cells to Oxaliplatin Chemotherapy: Suitability as a Biomarker for Patient Selection.” International Journal of Cancer, vol. 134, no. 6, 2014, pp. 1495–503.

Chicago Style

Hatch, S, L Swift, S Caporali, R Carter, E Hill, T Macgregor, S D'Atri, M Middleton, P McHugh, and R Sharma. 2014. “XPF Protein Levels Determine Sensitivity of Malignant Melanoma Cells to Oxaliplatin Chemotherapy: Suitability as a Biomarker for Patient Selection.” International Journal of Cancer 134 (6): 1495–1503.
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Publisher copy:: 10.1002/ijc.28454

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+ Hatch, S More by this author

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+ Swift, L More by this author

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+ Caporali, S More by this author

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+ Carter, R More by this author

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+ Hill, E More by this author

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Bibliographic Details

Journal:: International Journal of Cancer More from this journal
Volume:: 134
Issue:: 6
Pages:: 1495-1503
Publication date:: 2014-03-15
DOI:: 10.1002/ijc.28454
EISSN:: 1097-0215
ISSN:: 0020-7136

Item Description

Pubs id:: pubs:446969
UUID:: uuid:c47e3c79-32de-480d-a9ee-f72ec721e3a3
Local pid:: pubs:446969
Source identifiers:: 446969
Deposit date:: 2014-02-28

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Copyright date:: 2014

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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