ORA General item: "Timing language disorders with a chromosomal translocation in 7q31" - uuid:c45fd03e-c5c7-4f06-b504-5ba58755d5a6

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Reference: Paloma Garcia-Bellido, (2012). Timing language disorders with a chromosomal translocation in 7q31.

Citable link to this page: http://ora.ox.ac.uk/objects/uuid:c45fd03e-c5c7-4f06-b504-5ba58755d5a6
 
Title: Timing language disorders with a chromosomal translocation in 7q31

Abstract: The neural mechanisms of interval timing are not well understood. Language disorders provide a window for the search of the genetic basis of verbal communication which support the perception and execution of interval timing. Here we focus on the performance of a subject, A, with a chromosomal translocation t[7;11][p13;p13] along with a pericentromeric inversion with rupture points in 7p13 and 7q31, the latter being the locus of FOXP2. It was found that A significantly underperformed in a comprehension test with basic grammatical constructions compared to a Spanish population matched for age. It was also found that A underperformed in this perceptual test in both varieties compared to a control matched for age, sex, speech varieties, schooling and socioeconomic background. We found that there is a statistically significant correlation between A’s failure in understanding and the presence in the auditory stimulus of an interval in the range of 20-200ms, which happens to be crucial for the specific integration of longer intervals of the utterance. These findings are coherent with studies which suggest that the modulation of timing is supported by a functionally integrated network involving the striatum, thalamus cortex and cerebellum, where FOXP2 is expressed.


Publication status:Published
Peer Review status:Not peer reviewed
Version:Updated Author's Original
Digital Origin:Born digital
Notes:This is an updated version of a poster presented at the 3rd annual Oxford Neuroscience symposium 21/3/2012.
About The Authors
websitehttp://www.mod-langs.ox.ac.uk/bellido
institutionUniversity of Oxford
facultyHumanities Division - Medieval and Modern Languages Faculty - Spanish
facultyHumanities Division - Linguistics & Phonetics - Comparative Philology and General Linguistics
researchGroupDevelopmental language disorders: a Pilot study of a Spanish-Valencian bilingual with genetic disorder
oxfordCollegeSt Cross College
fundingJohn Fell Research Grant
grantNumber083/040
 
Contributors
Paloma Garcia-Bellido More by this contributor
RoleAuthor
 
Ladan Baghai-Ravary More by this contributor
RoleCollaborator
 
RoleCollaborator
 
Antonio Benítez-Burraco More by this contributor
RoleResearcher
 
Bibliographic Details
Creation Date: 2012-03-20
Copyright Date: 2012
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Urn: uuid:c45fd03e-c5c7-4f06-b504-5ba58755d5a6
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Member of collection : ora:conferenceitem
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Copyright Holder: Paloma Garcia-Bellido et al.
Access Condition: Restricted: Full content available from 2012-05-11 (ISO 8601)
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