Thesis

Analysis of the IgE network: Inhibition of CD23-mediated IgE upregulation and CD21/C3d interaction

Abstract:: Allergic reactions are mainly mediated by the interactions between the IgE and its ligands, amongst them CD23 and CD21 in what is termed the IgE network. CD23 is involved in upregulating IgE expression by forming a trimolecular complex with CD21 and IgE on the B-cell surface, resulting in the specific activation of IgE-positive B cells. CD21 also interacts with C3d and is a bridge between the innate and the immune system. A crystal structure of the interaction has been solved (Szakonyi et ...
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APA Style

Yahya, M., & YAHYA, M. O. H. D. N. O. R. H. A. K. I. M. (2011). Analysis of the IgE network: Inhibition of CD23-mediated IgE upregulation and CD21/C3d interaction [PhD thesis]. Oxford University, UK.

MLA Style

Yahya, M., and M. OH D. N. OR HA KI M. YAHYA. Analysis of the IgE Network: Inhibition of CD23-Mediated IgE Upregulation and CD21/C3d Interaction. Oxford University, UK, 2011.

Chicago Style

Yahya, M, and MOHD NORHAKIM YAHYA. 2011. “Analysis of the IgE Network: Inhibition of CD23-Mediated IgE Upregulation and CD21/C3d Interaction.” PhD thesis, Oxford University, UK.
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Files:: Dissemination_THESIS_NORHAKIM_YAHYA_2011.pdf

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Authors

+ Yahya, M More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Biochemistry
Oxford college:: Somerville College
Role:: Author

+ MOHD NORHAKIM YAHYA More by this author

Division:: MSD
Department:: Biochemistry
Role:: Author

Contributors

Division:: MSD
Department:: Biochemistry
Role:: Supervisor

Publication date:: 2011
Type of award:: DPhil
Level of award:: Doctoral
Awarding institution:: Oxford University, UK

Language:: English
Keywords:: asthma

complement

allergy

molecular biophysics

Immunoglobulin E

structural biology

X-ray crystallography
Subjects:: Molecular biophysics (biochemistry)

NMR spectroscopy

Biology (medical sciences)

Biochemistry

Immunochemistry
UUID:: uuid:bc5ff165-2d2c-4e4f-a0e9-5651cacd2ddf
Local pid:: ora:5693
Deposit date:: 2011-09-12

Terms of use

Copyright holder:: MOHD NORHAKIM YAHYA
Copyright date:: 2011

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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