Journal article
Hydrogen-borrowing and interrupted-hydrogen-borrowing reactions of ketones and methanol catalyzed by iridium
- Abstract:
- Reported herein is the use of catalytic [{Ir(cod)Cl}2] to facilitate hydrogen-borrowing reactions of ketone enolates with methanol at 65°C. An oxygen atmosphere accelerates the process, and when combined with the use of a bulky monodentate phosphine ligand, interrupts the catalytic cycle by preventing enone reduction. Subsequent addition of pronucleophiles to the reaction mixture allowed a one-pot methylenation/conjugate addition protocol to be developed, which greatly expands the range of products that can be made by this methodology.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
Bibliographic Details
- Publisher:
- Wiley
- Journal:
- Angewandte Chemie - International Edition More from this journal
- Volume:
- 54
- Issue:
- 5
- Pages:
- 1642-1645
- Publication date:
- 2015-01-26
- DOI:
- EISSN:
-
1521-3773
- ISSN:
-
1433-7851
Item Description
- Keywords:
- Pubs id:
-
pubs:506130
- UUID:
-
uuid:b1fa6879-e31b-40be-a371-912f5fdae19f
- Local pid:
-
pubs:506130
- Source identifiers:
-
506130
- Deposit date:
-
2015-07-10
Terms of use
- Copyright holder:
- Shen et al
- Copyright date:
- 2015
- Notes:
- Copyright © 2015 The Authors. Published by Wiley-VCH Verlag GmbH andmp; Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record