Thesis
The influence of BRCA1's ubiquitin ligase activity on cell motility
- Abstract:
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Breast cancer type 1 susceptibility protein (BRCA1) has been established as an important tumour suppressor protein and its loss of function is associated with hereditary breast and ovarian cancer. An emerging body of work suggests that BRCA1 is involved in sporadic cases of breast and ovarian cancers and may also have a role in other cancers, indicating a more global role in tumourigenesis. BRCA1-mutated cancers can be early-onset and are characterised by being highly aggressive with a ...
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(Supplementary materials, csv, 28.3MB, Terms of use)
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(Preview, Dissemination version, bin, 5.1MB, Terms of use)
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Authors
- Publication date:
- 2014
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- Keywords:
- Subjects:
- UUID:
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uuid:b14af4ae-1f95-4d0c-85a8-faaf4fa950c4
- Local pid:
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ora:8577
- Deposit date:
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2014-06-11
- ARK identifier:
Terms of use
- Copyright holder:
- Sengupta, S
- Copyright date:
- 2014
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