Thesis
The role of extra-thymic AIRE-expressing cells (eTACs) in AIRE-propagated immune tolerance
- Abstract:
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The autoimmune regulator (AIRE) is a facilitator of gene transcription found primarily in the thymus where its expression is localized primarily to mature medullary thymic epithelial cells (mTECs). AIRE modulates the promiscuous gene expression of tissue-restricted antigens (TRAs) and thus ensures that maturing T cells in the thymus are exposed to a broad array of peptides derived from self-antigens typically detected in peripheral tissues. Autoreactive thymocytes are deleted from the emer...
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(Preview, Version of record, pdf, 83.6MB, Terms of use)
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Authors
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- Keywords:
- Subjects:
- Deposit date:
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2021-10-07
- ARK identifier:
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- Copyright holder:
- Rosen, L
- Copyright date:
- 2021
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