Thesis
The synthesis and biological evaluation of novel N-acetylhexosaminidase inhibitors
- Abstract:
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Iminosugars are known to behave as carbohydrate mimics in biological systems by virtue of their similar structures. However as the ring nitrogen prevents metabolism it means that iminosugars have the potential to become inhibitors of these systems. It is known, for example, that iminosugars can behave as mimics in the hydrolysis mechanism. This leads to possible medicinal applications of iminosugars. One such case is lysosomal storage disorders which arise as a result of a genetic defect w...
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(Preview, pdf, 2.0MB, Terms of use)
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Authors
Contributors
+ Fleet, G
- Division:
- MSD
- Department:
- Biochemistry
- Role:
- Supervisor
+ Butters, T
- Division:
- MSD
- Department:
- Biochemistry
- Role:
- Supervisor
- Publication date:
- 2011
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
- Language:
-
English
- Keywords:
- Subjects:
- UUID:
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uuid:abe6fa1a-1922-45ee-b1f2-740247242129
- Local pid:
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ora:6580
- Deposit date:
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2012-11-28
- ARK identifier:
Terms of use
- Copyright holder:
- Elizabeth V. Crabtree
- Copyright date:
- 2011
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