Specialised transcription factories

Thesis

The intimate relationship between the higher-order chromatin organisation and the regulation of gene expression is increasingly attracting attention in the scientific community. Thanks to high-resolution microscopy, genome-wide molecular biology tools (3C, ChIP-on-chip), and bioinformatics, detailed structures of chromatin loops, territories, and nuclear domains are gradually emerging. However, to fully reveal a comprehensive map of nuclear organisation, some fundamental questions remain to b...

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Authors: Xu, M

• Publication date: 2008
• DOI: 10.5287/ora-dxpreoqej
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: 3C; in situ hybridisation; nuclear organisation; transcription factories; microarray; genomic; chromosome structure; chromosome; chromosome conformation; chromosome organisation; transcription; FISH; genome organisation; fluorescence microscopy; gene expression; genome; transcription wave
• Subjects: Biology (medical sciences); Microscopy; Molecular biophysics (biochemistry); Biochemistry; Genetics (life sciences); Molecular genetics; Life Sciences; Biology; Genetics (medical sciences); Pathology; Mammalian chromosome; Cell Biology (see also Plant sciences); Medical Sciences