Thesis
Regulation of T cell activation
- Abstract:
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Recognition of a cognate peptide-MHC molecule by its T cell receptor (TCR) triggers a critical cascade of protein re-organisation and clustering at the cell interface. This results in the formation of the immunological synapse (IS), concurrent with and influencing T cell activation. The glycoprotein CD2 with its ligand CD48 (mouse) or CD58 (human) has been shown to act as an important adhesion/co-stimulatory molecule influencing the T cell activation. While initial analysis of the knockout...
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- Files:
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(Preview, pdf, 19.4MB, Terms of use)
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Authors
Contributors
+ Dustin, M
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- NDORMS
- Sub department:
- Kennedy Institute for Rheumatology
- Role:
- Supervisor
+ Bowness, P
- Role:
- Supervisor
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- UUID:
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uuid:a20d2d22-bdc8-407e-a9b5-57d18ae6948a
- Deposit date:
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2018-10-15
- ARK identifier:
Terms of use
- Copyright holder:
- Demetriou, P
- Copyright date:
- 2018
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