Thesis
Genome-wide analysis of the hypoxic breast cancer transcriptome using next generation sequencing
- Abstract:
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Hypoxia pathways are associated with the pathogenesis of both ischaemic and neoplastic diseases. In response to hypoxia the transcription factor hypoxia‐inducible factor (HIF) induces the expression of hundreds of genes with diverse functions. These enable cells to adapt to low oxygen availability. To date, pan-genomic analyses of these transcriptional responses have focussed on protein-coding genes and microRNAs. However, the role of other classes of non-coding RNAs, in particular lncRNA...
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(Preview, Dissemination version, bin, 11.3MB, Terms of use)
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Authors
Contributors
+ Harris, A
- Division:
- MSD
- Department:
- NDM
- Role:
- Supervisor
+ Mole, D
- Division:
- MSD
- Department:
- NDM
- Role:
- Supervisor
+ King Abdulaziz University, Ministry of High Education, Saudi Arabia
More from this funder
- Funding agency for:
- Choudhry, H
- Publication date:
- 2014
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- Keywords:
- Subjects:
- UUID:
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uuid:9a66b553-a66c-4164-a854-5881be65ca45
- Local pid:
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ora:9613
- Deposit date:
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2014-12-17
- ARK identifier:
Terms of use
- Copyright holder:
- Choudhry, H
- Copyright date:
- 2014
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