Iminosugars as dengue virus therapeutics: Molecular mechanisms of action of a drug entering clinical trials

Thesis

Iminosugars are a class of small molecules defined by substitution of a sugar’s ring oxygen with nitrogen. Various chemical modifications of these basic structures (e.g. alkyl chain addition off of the ring nitrogen) have been developed during the last several decades. These molecules have been considered as therapeutics for a number of pathologies including viral infection, congenital disorders of glycosylation (of both glycoproteins and glycolipids), and diabetes. This thesis fo...

Expand abstract

Authors: Sayce, AC

• Publication date: 2014
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: immunology; iminosugar; cytokine storm; drug development; dengue; unfolded protein response; cytokine; glucosidase; calnexin cycle
• Subjects: Biochemistry; Medical Sciences; Glycobiology; Infectious diseases; Bioinformatics (life sciences); Viruses