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Thesis

The regulation of postsynaptic GABAA receptor signalling in epilepsy

Abstract:

Fast postsynaptic inhibition in the brain is mediated by ionotropic GABAA receptors (GABAARs), which are activated by the release of the neurotransmitter GABA from presynaptic interneurons. The GABAAR is primarily permeable to chloride ions (Cl-) and therefore the transmembrane gradient for Cl- sets the reversal potential of the receptor (EGABA-A). When intracellular Cl- concentrations are relatively low, EGABA-A is more neg...

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Authors

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Research group:
Colin Akerman
Oxford college:
University College
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Supervisor

More from this funder
Funding agency for:
Ilie, A-S

Publication date:
2013
DOI:
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

Language:
English
Keywords:
Subjects:
UUID:
uuid:8c9177f9-5fe0-4154-90ac-fb2df2b23338
Local pid:
ora:11709
Deposit date:
2015-06-23

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