Thesis
Computationally interrogating enzyme electrochemistry for rational mutation of metalloproteins
- Abstract:
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This thesis was inspired by an interest in the metalloenzymes: profoundly complex catalysts that perform the redox-mediated small molecule conversions that underpin the biosphere. The principal methodology is computational analysis of protein-film voltammetry (PFV), an experimental technique wherein an electro-active protein (such as a metalloenzyme) is chemically linked to an electrode, and subjected to a time-varying potential input, with a corresponding current response from two process...
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- Files:
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(Preview, Dissemination version, pdf, 61.2MB, Terms of use)
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Authors
Contributors
+ Parkin, A
- Role:
- Supervisor
+ Gavaghan, D
- Institution:
- University of Oxford
- Role:
- Supervisor
+ Robinson, M
- Institution:
- University of Oxford
- Division:
- MPLS
- Department:
- Computer Science
- Role:
- Supervisor
- ORCID:
- 0000-0002-1572-6782
+ Kathryn, G
- Role:
- Examiner
+ Fisher, A
- Role:
- Examiner
+ Engineering and Physical Sciences Research Council
More from this funder
- Funder identifier:
- http://dx.doi.org/10.13039/501100000266
- Grant:
- EP/L016494/1
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- Keywords:
- Subjects:
- Pubs id:
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2043499
- Local pid:
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pubs:2043499
- Deposit date:
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2022-10-10
- ARK identifier:
Terms of use
- Copyright holder:
- Lloyd-Laney, H
- Copyright date:
- 2021
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