Journal article

Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-κB.

Abstract:: An intriguing biological question relating to cell signaling is how the inflammatory mediator NF-kB and the tumour suppressor protein p53 can be induced by similar triggers, like DNA damage or infection, yet have seemingly opposing or sometimes cooperative biological functions. For example, the NF-κB subunit RelA/p65 has been shown to inhibit apoptosis, whereas p53 induces apoptosis. One potential explanation may be their co-regulation by common cellular factors: inhibitor of Apoptosis Stimul...
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Hu, Y., Ge, W., Wang, X., Sutendra, G., Zhao, K., Dedeić, Z., Slee, E., Baer, C., & Lu, X. (2015). Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-κB. Oncotarget, 6(40), 42478–42490.

MLA Style

Hu, Y., et al. “Caspase Cleavage of IASPP Potentiates Its Ability to Inhibit p53 and NF-ΚB.” Oncotarget, vol. 6, no. 40, Impact Journals, 2015, pp. 42478–90.

Chicago Style

Hu, Y, W Ge, X Wang, G Sutendra, K Zhao, Z Dedeić, E Slee, C Baer, and X Lu. 2015. “Caspase Cleavage of IASPP Potentiates Its Ability to Inhibit p53 and NF-ΚB.” Oncotarget 6 (40): 42478–90.
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Files:: Caspase cleavage of iASPP potentiates its ability to inhibit p...

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Publisher copy:: 10.18632/oncotarget.6478

Authors

+ Hu, Y More by this author

Institution:

University of Oxford

Division:

MSD

Department:

NDM

Sub department:

Oxford Ludwig Institute

Role:

Author

+ Ge, W More by this author

Role:

Author

+ Wang, X More by this author

Role:

Author

+ Sutendra, G More by this author

Institution:

University of Oxford

Division:

MSD

Department:

NDM

Sub department:

Oxford Ludwig Institute

Role:

Author

+ Zhao, K More by this author

Role:

Author

More authors...

Funding

+ National Nature Science 410 Foundation of China More from this funder

Grant:

31301131

+ Special Foundation for Distinguished 413 innovative Talents of Harbin More from this funder

Grant:

2014RFXXJ055

+ Natural Science Foundation of 412 Heilongjiang Province More from this funder

Grant:

C201431

+ Ministry of 411 Education of China More from this funder

Grant:

20132302120070

+ Ludwig Institute for Cancer Research More from this funder

Bibliographic Details

Publisher:: Impact Journals
Journal:: Oncotarget More from this journal
Volume:: 6
Issue:: 40
Pages:: 42478-42490
Publication date:: 2015-12-01
DOI:: 10.18632/oncotarget.6478
EISSN:: 1949-2553

Item Description

Language:: English
Keywords:: iASPP

caspase

RelA/p65

p53
Pubs id:: pubs:584150
UUID:: uuid:81f7754a-47f5-4d3d-87a0-e118bd963b4b
Local pid:: pubs:584150
Source identifiers:: 584150
Deposit date:: 2016-01-15

Terms of use

Copyright holder:: Hu et al
Copyright date:: 2015
Notes:: This article is licensed under a Creative Commons Attribution 3.0 License.

Licence:: CC Attribution (CC BY)

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