Evolutionary usage and developmental roles of vertebrate non-methylated DNA

Thesis

Vertebrate genomes exhibit global methylation of cytosine residues where they occur in a cytosine-guanine dinucleotide (CpG) context and this epigenetic mark is generally thought to be repressive to transcription. Punctuating this pervasive DNA methylation landscape are short, contiguous regions of non-methylated DNA which are found at two thirds of mammalian gene promoters. These non-methylated regions exhibit CpG content close to expected levels as they escape the depletion of CpGs...

Expand abstract

Authors: Long, HK

• Publication date: 2014
• DOI: 10.5287/ora-j1apbd0mw
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: mouse; CpG islands; vertebrates; frog; chicken; zebrafish; evolution; comparative genomics; non-methylated islands; platypus; DNA methylation; human; development; lizard
• Subjects: Bioinformatics (biochemistry); Biochemistry; Genetics (life sciences); Bioinformatics (life sciences); Biology; Evolution (zoology); Medical Sciences; Development (zoology); Cell Biology (see also Plant sciences)