Evolutionary usage and developmental roles of vertebrate non-methylated DNA

Thesis

Vertebrate genomes exhibit global methylation of cytosine residues where they occur in a cytosine-guanine dinucleotide (CpG) context and this epigenetic mark is generally thought to be repressive to transcription. Punctuating this pervasive DNA methylation landscape are short, contiguous regions of non-methylated DNA which are found at two thirds of mammalian gene promoters. These non-methylated regions exhibit CpG content close to expected levels as they escape the depletion of CpGs obse...

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Authors: Long, HK

• Publication date: 2014
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: CpG islands; development; zebrafish; platypus; frog; evolution; chicken; human; DNA methylation; lizard; comparative genomics; mouse; vertebrates; non-methylated islands
• Subjects: Medical Sciences; Biology; Evolution (zoology); Bioinformatics (biochemistry); Genetics (life sciences); Cell Biology (see also Plant sciences); Development (zoology); Biochemistry; Bioinformatics (life sciences)