New methods for nucleophilic fluorination

Thesis

This thesis describes investigations into the utility of boron fluorides and tetrafluoroborates as sources of nucleophilic fluorine.

Chapter 1 discusses the history and importance of the field of organofluorine chemistry and outlines some of the principle motivations for the site-selective fluorination of organic molecules. Some of the most commonly useed methods of nucleophilic fluorination are briefly surveyed, with an emphasis on the formation of fluorinated stereogenic centres. L...

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Authors: Cresswell, A

• Publication date: 2011
• DOI: 10.5287/ora-1akwykqyr
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: Oxford University, UK
• Language: English
• Keywords: epoxides; fluorination; boron trifluoride
• Subjects: Organic synthesis; Synthetic organic chemistry; Organic chemistry