Journal article
Cadherin2/4-signaling via PTP1B and catenins is critical for nucleokinesis during radial neuronal migration in the neocortex
- Abstract:
-
Cadherins are critical for the radial migration of excitatory projection neurons into the developing neocortical wall. However, the specific cadherins and the signaling pathways that regulate radial migration are not well understood. Here we show that cadherin 2 (CDH2) and CDH4 cooperate to regulate radial migration via the protein tyrosine phosphatase 1B (PTP1B) and α- and β-catenins. Surprisingly, perturbation of cadherin-mediated signaling does not affect the formation and extension of lea...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
+ National Institutes of Health
More from this funder
Name:
National Institutes of Health
Funding agency for:
Franco, S
Mueller, U
Grant:
NS060355
HD070494
+ Generalitat Valenciana
More from this funder
Name:
Generalitat Valenciana
Funding agency for:
Gil-Sanz, C
Grant:
EX2009-0416
+ Spanish Ministerio de Educacion, Cultura y Deporte
More from this funder
Name:
Spanish Ministerio de Educacion, Cultura y Deporte
Funding agency for:
Martinez-Garay, I
Gil-Sanz, C
Grant:
FU-2006-1238
EX2009-0416
+ California Institute for
Regenerative Medicine
More from this funder
Name:
California Institute for
Regenerative Medicine
Funding agency for:
Martinez-Garay, I
Espinosa, A
Grant:
FU-2006-1238
Bibliographic Details
- Publisher:
- Company of Biologists
- Journal:
- Development More from this journal
- Volume:
- 143
- Issue:
- 12
- Pages:
- 2121-2134
- Publication date:
- 2016-06-06
- Acceptance date:
- 2016-04-26
- DOI:
- EISSN:
-
1477-9129
- ISSN:
-
0950-1991
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:622956
- UUID:
-
uuid:5eec6acc-e294-4cb0-b121-bd5d15451cf2
- Local pid:
- pubs:622956
- Source identifiers:
-
622956
- Deposit date:
- 2016-06-20
Terms of use
- Copyright holder:
- Martinez-Garay et al
- Copyright date:
- 2016
- Notes:
- © 2016. Published by The Company of Biologists Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
- Licence:
- CC Attribution (CC BY)
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