Thesis
Ultrasound segmentation tools and their application to assess fetal nutritional health
- Alternative title:
- Feature Asymmetry, Live Wire and shape models, applied to the measurement of fetal fat, liver and facial shape
- Abstract:
-
Maternal diet can have a great impact on the health and development of the fetus. Poor fetal nutrition has been linked to the development of a set of conditions in later life, such as coronary heart disease, type 2 diabetes and hypertension, while restricted growth can result in hypogylcemia, hypocalcemia, hypothermia, polycythemia, hyperbilirubinemia and cerebral palsy. High alcohol consumption during pregnancy can result in Fetal Alcohol Syndrome, a condition that can cause growth retardation, lowered intelligence and craniofacial defects. Current biometric assessment of the fetus involves size-based measures which may not accurately portray the state of fetal development, since they cannot differentiate cases of small-but-healthy or large-but-unhealthy fetuses.
This thesis aims to outline a set of more appropriate measures of accurately capturing the state of fetal development. Specifically, soft tissue area and liver volume measurement are examined, followed by facial shape characterisation.
A number of tools are presented which aim to allow clinicians to achieve accurate segmentations of these landmark regions. These are modifications on the Live Wire algorithm, an interactive segmentation method in which the user places a number of anchor points and a minimum cost path is calculated between the previous anchor point and the cursor. This focuses on giving the clinician intuitive control over the exact position of the segmented contour.
These modifications are FA-S Live Wire, which utilises Feature Asymmetry and a weak shape constraint, ASP Live Wire, which is a 3D expansion of Live Wire, and FA-O Live Wire, which uses Feature Asymmtery and Local Orientation to guide the segmentation process. These have been designed with each of the specific biometric landmarks in mind.
Finally, a method of characterising fetal face shape is proposed, using a combination of the segmentation methods described here and a simple shape model with a parameterised b-spline meshing approach to facial surface representation.
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Authors
Contributors
+ Hammond, P
- Institution:
- University of Oxford
- Division:
- MSD
- Role:
- Contributor
+ Papageorghiou, A
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Women's & Reproductive Health
- Role:
- Contributor
+ Gooding, M
- Institution:
- Mirada Medical
- Role:
- Contributor
+ Stebbing, R
- Institution:
- University of Oxford
- Division:
- MPLS
- Department:
- Engineering Science
- Role:
- Contributor
+ Knight, C
- Institution:
- University of Oxford
- Division:
- MSD
- Role:
- Contributor
+ Engineering and Physical Sciences Research Council
More from this funder
- Funder identifier:
- https://ror.org/0439y7842
- Grant:
- Centre for Doctoral Training in Healthcare Innovation EP/G036861/1
+ National Institute on Alcohol Abuse and Alcoholism
More from this funder
- Funder identifier:
- https://ror.org/02jzrsm59
- Grant:
- As a developmental project of the Administrative Core of the CIFASD consortium NIH U24AA014811
+ Wellcome Trust/Engineering and Physical Sciences Research Council
More from this funder
- Grant:
- Centre of Excellence 088877/Z/09/Z
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- Keywords:
- Subjects:
- UUID:
-
uuid:5d102b18-dd32-4004-8aa5-b04242139daa
- Deposit date:
-
2016-04-23
Terms of use
- Copyright holder:
- T.M. Rackham
- Copyright date:
- 2015
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