Thesis
The mechanism of Nov (CCN3) function in haematopoiesis
- Abstract:
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Haematopoietic stem cells (HSC) are strictly regulated by intrinsic regulators and extrinsic signals from the microenvironment. Nov (CCN3), a matricellular protein of the CCN family, has been reported as a suppressor gene in solid tumours and chronic myeloid leukaemia (CML). Recent study identified Nov as a positive regulator in human cord blood CD34+ stem cells. However, the functions of Nov in haematopoiesis and adult HSC remain largely unknown.
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- Files:
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(bin, 4.2MB, Terms of use)
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Authors
Contributors
+ Enver, T
- Division:
- MSD
- Department:
- RDM
- Sub department:
- RDM Clinical Laboratory Sciences
- Role:
- Supervisor
+ Vyas, P
- Division:
- MSD
- Department:
- RDM
- Sub department:
- RDM Clinical Laboratory Sciences
- Role:
- Supervisor
- Publication date:
- 2012
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- Keywords:
- Subjects:
- UUID:
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uuid:5785f3b9-3206-4bb4-b486-d90cded680f8
- Local pid:
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ora:10998
- Deposit date:
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2015-04-14
- ARK identifier:
Terms of use
- Copyright holder:
- Guo, Y
- Copyright date:
- 2012
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