Type II diabetes of early onset: a distinct clinical and genetic syndrome?

Journal article

The inheritance of non-insulin-dependent (type II) diabetes was studied by a continuous infusion of glucose test in all available first degree relatives of 48 diabetic probands of various ages and with differing severity of disease. In an initial study of 38 type II diabetic subjects and their first degree relatives six islet cell antibody negative patients with early onset disease (aged 25-40 at diagnosis) were found to have a particularly high familial prevalence of diabetes or glucose into...

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Authors: O'Rahilly, S; Spivey, R; Holman, R; Nugent, Z; Clark, A

• Publication status: Published
• Journal: British medical journal (Clinical research ed.)
• Volume: 294
• Issue: 6577
• Pages: 923-928
• Publication date: 1987-04-01
• ISSN: 0267-0623
• Language: English
• Keywords: Sex Factors; C-Peptide; Pedigree; Female; Blood Glucose; Adult; Middle Aged; Diabetes Mellitus, Type 2; Age Factors; Male; Obesity; Humans; Diabetes Mellitus