Thesis
The role of RAD51-like genes in the repair of DNA damage in mammalian cells
- Abstract:
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Homologous recombination (HR) is essential for the repair of severe forms of DNA damage such as double strand breaks and interstrand cross-links. The highly conserved RAD51 protein is central to this process and forms nucleoprotein filaments on ssDNA that catalyse strand exchange. In mammalian cells, five genes that share sequence homology with RAD51 have been identified; XRCC2, XRCC3, RAD5JL1, RAD51L2 and RAD51L3. Interactions amongst the RAD51-like proteins have been de...
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(Preview, pdf, 15.4MB, Terms of use)
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Authors
- Publication date:
- 2003
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- Subjects:
- UUID:
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uuid:3408a30d-8833-4649-8d72-7194c60f944c
- Local pid:
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td:603877177
- Source identifiers:
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603877177
- Deposit date:
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2013-01-18
- ARK identifier:
Terms of use
- Copyright holder:
- French, C
- Copyright date:
- 2003
- Notes:
- The digital copy of this thesis has been made available thanks to the generosity of Dr Leonard Polonsky
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