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Thesis

Structural, biochemical and computational studies of TRP channel transmembrane domain modularity

Abstract:

Transient receptor potential (TRP) channels are expressed throughout the central nervous system and have a unique ability to detect a wide range of stimuli including changes in voltage, temperature, pH, lipid environment, small molecule agonists, and mechanical stress. While it is known that TRP channels contain the same six transmembrane helix (S1-S6), tetrameric architecture as voltage-gated channels, the degree to which functional and structural analogies are relevant remains poorly und...

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Research group:
Prof. Mark S. P. Sansom and Prof. Simon Newstead
Oxford college:
Christ Church
Role:
Author

Contributors

Division:
MSD
Department:
Biochemistry
Role:
Supervisor
Division:
MSD
Department:
Biochemistry
Role:
Supervisor

Publication date:
2014
DOI:
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

Language:
English
Keywords:
Subjects:
UUID:
uuid:328269a9-11c0-4d5b-9cb7-d7433cf4d6c4
Local pid:
ora:10491
Deposit date:
2015-03-11

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