Computational studies of protein dynamics and dynamic similarity

Thesis

At the time of writing this thesis, the complete genomes of more than 180 organisms have been sequenced and more than 80000 biological macromolecular structures are available in the Protein Data Bank (PDB). While the number of sequenced genomes and solved three-dimensional structures are rapidly increasing, the functional annotation of protein sequences and structures is a much slower process, mostly because the experimental de-termination of protein function is expensive and time-consumin...

Expand abstract

Authors: Munz, M

• Publication date: 2012
• DOI: 10.5287/ora-r1vyx8mw7
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: Oxford University, UK
• Language: English
• Keywords: flexibility; PDZ domains; protein dynamics; molecular dynamics simulations
• Subjects: Bioinformatics (life sciences); Bioinformatics (biochemistry); Computational biochemistry