Approach to study the brain: towards the early detection of neurodegenerative disease

Thesis

Neurodegeneration is a progressive loss of neuron function or structure, including death of neurons, and occurs at many different levels of neuronal circuitry. In this thesis I discuss Parkinson’s Disease (PD), the second most common neurodegenerative disease (NDD). PD is a devastating progressive NDD often with delayed diagnosis due to detection methods that depend on the appearance of visible motor symptoms. By the time cardinal symptoms manifest, 60 to 80 percent or more of the dopamine...

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Authors: Howard, N

• Publication date: 2014
• DOI: 10.5287/ora-qzxak8r2b
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: Oxford University, UK
• Language: English
• Keywords: Bioinformatics (life sciences); Neuropathology; Theoretical Neuroscience; Disease prevention; Medical Sciences; Muscle & Nerve (Neuroscience); Genetics (medical sciences); Neuropsychology; Neurogenetics; Geratology; Organisation and evaluation of medical care
• Subjects: Neurology; Bioinformatics (life sciences); Computational Neuroscience; Organisation and evaluation of medical care; Theoretical Neuroscience; Neuroscience; Disease prevention; Medical Sciences; Surgery; Genetics (medical sciences); Neuropsychology; Neurogenetics; Geratology; Cognitive Neuroscience; Neuropathology; Muscle & Nerve (Neuroscience); Motor neurone degenerative disease; Old Age psychiatry