Thesis

Studies on enzymes mechanism and selectivity using synthetic substrate analogues

Abstract:: Organic chemistry is a valuable tool for studying enzyme mechanisms. Upon incubation with a specific enzyme, synthetic substrate analogues labeled with heavy atoms or carrying extra functional groups can provide mechanistic insights. In the present work, new compounds were synthesised in order to study the mechanism and substrate selectivity of two enzymes: human γ-butyrobetaine hydroxylase and bacterial carboxymethylproline synthase.

γ-Butyrobetaine hydroxylase (BBOX) is an Fe(II) a...
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APA Style

Henry, L. (2012). Studies on enzymes mechanism and selectivity using synthetic substrate analogues [PhD thesis]. Oxford University, UK.

MLA Style

Henry, L. Studies on Enzymes Mechanism and Selectivity Using Synthetic Substrate Analogues. Oxford University, UK, 2012.

Chicago Style

Henry, L. 2012. “Studies on Enzymes Mechanism and Selectivity Using Synthetic Substrate Analogues.” PhD thesis, Oxford University, UK.
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Files:: Final_Thesis_Luc_Henry_2012_dissemination.pdf

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Authors

+ Henry, L More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

Contributors

Role:: Supervisor

+ Berrow Foundation More from this funder

Funding agency for:: Henry, L

Publication date:: 2012
Type of award:: DPhil
Level of award:: Doctoral
Awarding institution:: Oxford University, UK

Language:: English
Keywords:: Carnitine

Carbapenems

structural biology

enzymology

biosynthesis
Subjects:: Chemical biology
UUID:: uuid:21234b44-3778-46c6-9a08-9351f6411f4e
Local pid:: ora:9683
Deposit date:: 2015-01-07

Terms of use

Copyright holder:: Henry, L
Copyright date:: 2012

Licence:: CC Attribution-ShareAlike (CC BY-SA)

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