The synthesis of azetidine and piperidine iminosugars from monosaccharides

Thesis

Iminosugars are polyhydroxylated alkaloids, and can be generally defined as sugar mimetics in which the endocyclic oxygen atom has been replaced with a basic nitrogen. A common affect of this atomic substitution is to bestow these compounds with the ability to inhibit various sugarprocessing enzymes; most significantly the glycosidases (glycoside hydrolases) which areintimately involved in a huge array of biological functions. Compounds which inhibit these enzymes concordantly possess much...

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Authors: Lenagh-Snow, G; Gabriel M.J. Lenagh-Snow

• Publication date: 2012
• DOI: 10.5287/ora-jv0yn7z61
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: Oxford University, UK
• Language: English
• Keywords: glycomimetic; bioactive; 2; iminosugar; biotechnology; glycosidase inhibitor; azetidine; 6-iminoheptitol; Organic chemistry; synthesis; homonojirimycin
• Subjects: Organic synthesis; Synthetic organic chemistry; Organic chemistry