Sleep, circadian and behavioural characterisation of two schizophrenia-relevant transgenic mouse models

Thesis

The experiments described in this thesis involved the sleep, circadian and behavioural characterisation of two schizophrenia-relevant transgenic mouse models, both of which are models of altered glutamatergic function. Although schizophrenia cannot be recapitulated in rodents, the study of transgenic mouse models can yield insights into the roles of schizophrenia candidate genes in brain function and dysfunction.

D-amino acid oxidase knockout (Dao^-/-) mi...

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Authors: Pritchett, D

• Publication date: 2015
• DOI: 10.5287/ora-2njdnd92k
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: memory; mouse model; Sleep; anxiety; schizophrenia; circadian rhythm; glutamate
• Subjects: Neuroscience; Psychiatry