Stochastic modelling of the cell cycle

Thesis

Precise regulation of cell cycle events by the Cdk-control network is essential for cell proliferation and the perpetuation of life. The unidirectionality of cell cycle progression is governed by several critical irreversible transitions: the G1-to-S transition, the G2-to-M transition, and the M-to-G1 transition. Recent experimental and theoretical evidence has pulled into question the consensus view that irreversible protein degradation causes the irreversibility of those transitions. A n...

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Authors: He, E

• Publication date: 2012
• DOI: 10.5287/ora-veqbpkm6g
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: Oxford University, UK
• Language: English
• Keywords: cell cycle; stochastic; spindle assembly checkpoint; irreversible transitions; mitotic exit
• Subjects: Cell Biology (see also Plant sciences); Computational biochemistry; Molecular biophysics (biochemistry); Biochemistry; Mammalian chromosome